Bioperine, a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). It contains 95 percent of piperine. Bioperine is used in conjunction with other herbs or vitamins to increase their absorption and digestion to make them more effective.

Caffeine is a powerful and very common alkaloid supplement used in ThermoLean primarily to increase the body’s ability to lose weight quickly, boost energy and stimulate the brain into more activity with better clarity. It also fuels the body’s metabolism for increased fat burning qualities. This allows users to have more stamina for exercise and more focus for weight loss initiatives. Caffeine anhydrous is found naturally in many different beans and plants and works successfully as a stimulating supplement for those needing increased energy, focus, and alertness. When taken as a supplement for health or weight loss reasons, caffeine anhydrous should not be combined with other traditional forms of caffeine, such as soft drinks, energy drinks, coffee, or tea, because the supplement form is concentrated and powerful in itself.

Guggulsterone is a plant sterol found in the resin of the guggul plant, Commiphora mukul. It acts as an antagonist of the farnesoid X receptor, which was earlier believed to result in decreased cholesterol synthesis in the liver.

Synephrine is a drug that is deemed to selectively bind to and also activate alpha adrenergic receptors. Mainly used as a vasoconstrictor in asthma, glaucoma, circulatory failure and nasal congestion, this compound is currently propagated as a weight loss agent. The alleged function synephrine is providing include fat burning, energy level and metabolism increase and promotion of weight loss. Synephrine, also known as oxedrine, is the widely accepted replacement for ephedrine. The natural source of synephrine is the citrus aurantium fruit, better known as bitter orange. Bitter orange extracts, which contain synephrine, are known to stimulate the alpha-1 adrenergic receptor, thereby constricting blood vessels and increasing the heart rate as well as blood pressure, effecting in an increased energy use.

Yohimbe- Basically a tree bark, Yohimbe is rich in pharmacologically active chemicals. It is commonly found in products developed for body building and enhancing male performance. The use of Yohimbe causes serious side effects too that include renal failure, seizures and in very rare cases, even death. Individuals suffering from low blood pressure, heart disease, liver or kidney disease, and diabetes should refrain from using any kind of Yohimbe supplements. Taking larger doses of Yohimbe can cause weakness, stomach disorders, fatigue, and nervous stimulation followed by paralysis. It is therefore important to avoid self-medication. Sometimes, side effects may arise even if small amounts of this supplement are taken, especially for prolonged periods. If you are already taking drugs for treating some health condition, it is best to avoid this supplement.